Metformin Reduces Lipogenesis Markers in Obese Mice Fed a Low-Carbohydrate and High-Fat Diet

This study showed that metformin decreased adipocyte area, body weight and food consumption in obese animals when compared to the standard group. Furthermor e, the expression of lipogenic markers in adipose tissue were diminished in obese animals treated with metformin. This data showed that oral administration of metformin improved glucose and lipid metabolic parameters in white adipose tissue by reducing the expression of lipogenesis markers, suggesti ng an important clinical application of MET in treating obesity-related diseases in metabolic syndrome.
Source: Lipids - Category: Lipidology Source Type: research