Supplementation of oligofructose, but not sucralose, decreases high ‐fat diet induced body weight gain in mice independent of gustducin‐mediated gut hormone release

ConclusionOFS, but not sucralose, reduced body weight gain and decreased intestinal permeability, but not glucose intolerance. Effects were not mediated by altered gut hormone levels or gustducin‐mediated signaling.Artificial sweeteners do not affect gut hormone levels and are metabolically inert in mice on a high fat diet. In contrast, prebiotic oligosaccharides (OFS) prevent body weight gain but not glucose intolerance. Alterations in sweet and short‐chain fatty acid receptors (FFAR) (studied in WT and α‐gust−/− mice) which regulate gut hormone levels are not mandatory for the positive effects of OFS. Enhanced uptake of SCFAs may favor interaction with FFAR2/3 on adipose tissue to induce weight loss.This article is protected by copyright. All rights reserved

Source: Nahrung / Food - October 30, 2016 Category: Nutrition Authors: Sandra Steensels, Leen Cools, Bert Avau, Laurien Vancleef, Ricard Farr é, Kristin Verbeke, Inge Depoortere Tags: Research Article Source Type: research