Inhibition of Prostaglandin E2 By Low-Dose Aspirin

In conclusion, low-dose aspirin has a significant effect on extraplatelet cyclooxygenase and potently inhibits COX-2 in lung and colon adenocarcinoma cells. This supports a hypothesis that the remarkable prevention of metastasis from adenocarcinomas, and particularly from colon adenocarcinomas, by low-dose aspirin results from its effect on platelet COX-1 combined with inhibition of PGE2 biosynthesis in metastasizing tumor cells. Cancer Prev Res; 9(11); 855–65. ©2016 AACR.

Source: Cancer Prevention Research - October 30, 2016 Category: Cancer & Oncology Authors: Boutaud, O., Sosa, I. R., Amin, T., Oram, D., Adler, D., Hwang, H. S., Crews, B. C., Milne, G., Harris, B. K., Hoeksema, M., Knollmann, B. C., Lammers, P. E., Marnett, L. J., Massion, P. P., Oates, J. A. Tags: Research Articles Source Type: research