Neurokinin-1 Receptor Antagonist-Based Triple Regimens in Preventing Chemotherapy-Induced Nausea and Vomiting: A Network Meta-Analysis

Conclusions: Different NK-1RAs-based triple regimens shared equivalent effect on CINV control. Various triple regimens had superior antiemetic effect than duplex regimen in patients with HEC. Only aprepitant-based triple regimen showed better CINV control compared with duplex regimen in patients receiving MEC. Palonosetron and first-generation 5HT3RAs might share equivalent CINV control in the combination of NK-1RAs and dexamethasone. Lower doses of dexamethasone might be applied when used with NK-1RAs and 5HT3RAs.

Source: JNCI - October 29, 2016 Category: Cancer & Oncology Authors: Zhang, Y., Yang, Y., Zhang, Z., Fang, W., Kang, S., Luo, Y., Sheng, J., Zhan, J., Hong, S., Huang, Y., Zhou, N., Zhao, H., Zhang, L. Tags: Review Source Type: research