Pharmacological considerations for predicting PK/PD at the site of action for therapeutic proteins

Publication date: Available online 22 October 2016 Source:Drug Discovery Today: Technologies Author(s): Weirong Wang, Honghui Zhou For therapeutic proteins whose sites of action are distal to the systemic circulation, both drug and target concentrations at the tissue sites are not necessarily proportional to those in systemic circulation, highlighting the importance of understanding pharmacokinetic/pharmacodynamic (PK/PD) relationship at the sites of action. This review summarizes the pharmacological considerations for predicting local PK/PD and the importance of measuring PK and PD at site of action. Three case examples are presented to show how mechanistic and physiologically based PK/PD (PBPK/PD) models which incorporated the PK and PD at the tissue site can be used to facilitate understanding the exposure-response relationship for therapeutic proteins.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research