Translational PK/PD of anti-infective therapeutics

Publication date: Available online 28 October 2016 Source:Drug Discovery Today: Technologies Author(s): Chetan Rathi, Richard E. Lee, Bernd Meibohm Translational PK/PD modeling has emerged as a critical technique for quantitative analysis of the relationship between dose, exposure and response of antibiotics. By combining model components for pharmacokinetics, bacterial growth kinetics and concentration-dependent drug effects, these models are able to quantitatively capture and simulate the complex interplay between antibiotic, bacterium and host organism. Fine-tuning of these basic model structures allows to further account for complicating factors such as resistance development, combination therapy, or host responses. With this tool set at hand, mechanism-based PK/PD modeling and simulation allows to develop optimal dosing regimens for novel and established antibiotics for maximum efficacy and minimal resistance development.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research