Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease

Conclusions. Endothelial function is impaired in nonsevere and severe vivax malaria, is associated with reduced L-arginine bioavailability, and may contribute to microvascular pathogenesis. Severe disease appears to be more associated with extravascular hemolysis than with intravascular hemolysis.

Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Authors: Barber, B. E., William, T., Grigg, M. J., Piera, K. A., Chen, Y., Wang, H., Weinberg, J. B., Yeo, T. W., Anstey, N. M. Tags: PARASITES Source Type: research