T-Cell Immunoglobulin- and Mucin-Domain-Containing Molecule 3 Signaling Blockade Improves Cell-Mediated Immunity Against Malaria

In conclusion, Tim-3 on immune cells negatively regulates cell-mediated immunity against Plasmodium infection, and blocking Tim-3 signaling enhances sterile immunity and may play a protective role during malarial parasite infections.

Source: The Journal of Infectious Diseases - October 27, 2016 Category: Infectious Diseases Authors: Hou, N., Zou, Y., Piao, X., Liu, S., Wang, L., Li, S., Chen, Q. Tags: PARASITES Source Type: research