Imaging in Central Nervous System Drug Discovery

The discovery and development of central nervous system (CNS) drugs is an extremely challenging process requiring large resources, timelines, and associated costs. The high risk of failure leads to high levels of risk. Over the past couple of decades PET imaging has become a central component of the CNS drug-development process, enabling decision-making in phase I studies, where early discharge of risk provides increased confidence to progress a candidate to more costly later phase testing at the right dose level or alternatively to kill a compound through failure to meet key criteria.

Source: Seminars in Nuclear Medicine - October 27, 2016 Category: Nuclear Medicine Authors: Roger N. Gunn, Eugenii A. Rabiner Source Type: research