Humanin ameliorates diazepam-induced memory deficit in mice

Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively.

Source: Neuropeptides - October 27, 2016 Category: Neuroscience Authors: Minetaka Murakami, Masatoshi Nagahama, Takuma Maruyama, Takako Niikura Source Type: research