Talimogene laherparepvec (T-Vec) for the treatment of melanoma and other cancers

Talimogene laherparepvec (T-Vec) is the first live virus to be approved by the FDA for the treatment of cancer. This engineered version of herpes simplex virus type 1 (HSV-1) is the product of decades of preclinical work aimed at identifying and modifying aspects of the viral genome involved in virulence and immunogenicity. T-Vec preferentially infects and lyses tumor cells and, in some cases, induces a systemic immune response against the tumor. These properties have translated into significant and durable clinical responses, particularly in advanced melanoma.
Source: Seminars in Oncology - Category: Cancer & Oncology Authors: Source Type: research