Evaluation of two nucleophilic syntheses routes for the automated synthesis of 6-[18F]Fluoro-l-DOPA

Two different strategies for the nucleophilic radiosynthesis of [18F]F-DOPA were evaluated regarding their applicability for an automated routine production on an Ecker&Ziegler Modular-Lab Standard module.Initially, we evaluated a promising 5-step synthesis based on a chiral, cinchonidine-derived phase-transfer catalyst (cPTC) being described to give the product in high radiochemical yields (RCY), high specific activities (AS) and high enantiomeric excesses (ee). However, the radiosynthesis of [18F]F-DOPA based on this strategy showed to be highly complex, giving the intermediate products as well as the final product in insufficient yields for automatization.

Source: Nuclear Medicine and Biology - October 26, 2016 Category: Nuclear Medicine Authors: M. Pretze, D. Franck, F. Kunkel, E. Fo ßhag, C. Wängler, B. Wängler Source Type: research