Evaluation of histopathological changes in the microstructure at the center and periphery of glioma tumors using diffusional kurtosis imaging

Gliomas are the most common intrinsic brain tumor of the central nervous system. Glioma tissues are inhomogeneous in nature. In the process of malignant transformation, the histopathological characteristics of the tumor will change drastically, mirroring the changes in tumor microstructure [1]. Conventional MR imaging techniques have documented the macrostructural changes in gliomas [2]. However, detection of these changes at the microstructural level is limited using these techniques; for example, during the course of tumor progression gliomas exhibit increased levels of cellularity, micronecrosis and vascular hyperplasia.

Source: Clinical Neurology and Neurosurgery - October 26, 2016 Category: Neurosurgery Authors: Fuyan Li, Wenqi Shi, Dawei Wang, Yanjie Xu, Hongxia Li, Jingzhen He, Qingshi Zeng Tags: Full length article Source Type: research