Computationally Efficient Analysis of Particle Transport and Deposition in a Human Whole-Lung-Airway Model. Part I: Theory and Model Validation

Computational predictions of aerosol transport and deposition in the human respiratory tract can assist in evaluating detrimental or therapeutic health effects when inhaling toxic particles or administering drugs. However, the sheer complexity of the human lung, featuring a total of 16 million tubular airways, prohibits detailed computer simulations of the fluid-particle dynamics for the entire respiratory system. Thus, in order to obtain useful and efficient particle deposition results, an alternative modeling approach is necessary where the whole-lung geometry is approximated and physiological boundary conditions are implemented to simulate breathing.

Source: Computers in Biology and Medicine - October 26, 2016 Category: Bioinformatics Authors: Arun V Kolanjiyil, Clement Kleinstreuer Source Type: research