p53 partners with RNA in the DNA damage response

Nature Genetics 48, 1298 (2016). doi:10.1038/ng.3702 Author: Maite Huarte Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.

http://feeds.nature.com/~r/ng/rss/current/~3/2UPl0ME-DWQ/ng.3702

Source: Nature Genetics - October 26, 2016 Category: Genetics & Stem Cells Authors: Maite Huarte Tags: News and Views Source Type: research

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