Activating ATR, the devil's in the dETAA1l

Nature Cell Biology 18, 1120 (2016). doi:10.1038/ncb3431 Author: Wojciech Niedzwiedz Two studies now show that Ewing's tumour-associated antigen 1 (ETAA1) is recruited to sites of DNA replication stress through its interaction with replication protein A, where it stimulates the ATR kinase to promote efficient genome duplication. These findings provide exciting insight into the already very complex regulatory mechanism of the ATR activation cascade.

http://feeds.nature.com/~r/ncb/rss/current/~3/u5ZFW2c77Jk/ncb3431

Source: Nature Cell Biology - October 26, 2016 Category: Cytology Authors: Wojciech Niedzwiedz Tags: News and Views Source Type: research

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