Melanin biosynthesis in pathogenic species of Sporothrix

Publication date: Available online 18 October 2016 Source:Fungal Biology Reviews Author(s): Rodrigo Almeida-Paes, Luana Pereira Borba-Santos, Sonia Rozental, Sergio Marco, Rosely Maria Zancopé-Oliveira, Marcel Menezes Lyra da Cunha Melanins are dark polymers found in the cell wall of pathogenic fungi, including species from the genus Sporothrix that are causative agents of sporotrichosis. In vitro experiments strongly suggest that these pigments are important for fungal virulence and survival in the host. In S. schenckii, melanin biosynthesis occurs via three different common pathways, which generate dihydroxynaphthalene (DHN)-melanin, DOPA-melanin or pyomelanin. Moreover, melanin biosynthesis can be enhanced when the fungus is in contact with some bacteria, such as Pseudomonas aeruginosa and Klebsiella pneumoniae. Melanin pigments have protective effects against antifungals in this genus. New scanning transmission electron tomography data indicates the accumulation of dark pigments in membrane-bound cytoplasmic organelles (melanosomes) in S. schenckii yeasts. Here, we provide an up to date of review the biosynthesis and role of melanins and discuss its roles on the cell biology and pathogenesis of Sporothrix spp.

Source: Fungal Biology Reviews - October 25, 2016 Category: Biology Source Type: research