Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis

Conclusions The data for the first time revealed specific signaling pathways leading to cyclophosphamide-induced bladder hyperactivity and pain, including the activation of mTOR and PI3K. Inhibition of these pathways alleviates cystic pain. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of overactive bladder and pain often observed in cystitis.
Source: Molecular Pain - Category: Molecular Biology Authors: Tags: Research Article Source Type: research