Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review

ConclusionsTopical ketoprofen in Transfersome gel is an effective means of treating symptoms of knee OA, and is superior to oral celecoxib, oral placebo and topical placebo. The most commonly reported adverse events associated with the use of topical ketoprofen in Transfersome gel were non‐severe skin and subcutaneous tissue disorders. Furthermore, as topical ketoprofen in Transfersome gel was associated with fewer adverse events when compared with oral celecoxib, and had rates of GI adverse events comparable with those of topical placebo, it may be ideal for those who are unable to take oral NSAIDs.

Source: Musculoskeletal Care - August 31, 2016 Category: Physiotherapy Authors: Vandit Sardana, Joanna Burzynski, Paul Zalzal Tags: LITERATURE REVIEW Source Type: research