Current Practice on Multiplicity Adjustment and Sample Size Calculation in Multi-arm Clinical Trials: An Industry Survey in Japan

Conclusions:
To adequately design a multi-arm clinical trial, it is important within sample size calculation to consider whether to perform multiplicity adjustment, select MCPs, and define their power.

Source: Therapeutic Innovation and Regulatory Science - October 23, 2016 Category: Drugs & Pharmacology Authors: Sakamaki, K., Kamiura, T., Morita, Y., Iba, K., Yoshida, S., Wakana, A., Tsuchiya, S., Fukimbara, S., Suganami, H. Tags: Statistics Source Type: research