Formaldehyde exposure inhibits the expression of mammalian target of rapamycin in rat testis

In this study, immunohistochemistry, Western blotting, and reverse transcription polymerase chain reaction analysis were used to detect the expression of mTOR molecule in testicular tissues. We found that FA exposure inhibits the expression of mTOR in a dose-dependent manner. Combined with our earlier finding, we found the decreasing expression of mTOR in testicular tissue were consistent with the changes of testicular structure and autophagy levels. In summary, our data suggested that mTOR molecule might be involved in male reproductive injuries induced by FA exposure.

Source: Toxicology and Industrial Health - October 23, 2016 Category: Toxicology Authors: Fang, J., Li, D.-h., Yu, X.-q., Lv, M.-q., Bai, L.-z., Du, L.-z., Zhou, D.-x. Tags: Articles Source Type: research