Nucleoprotein supplementation enhances the recovery of rat soleus mass with reloading after hindlimb unloading-induced atrophy via myonuclei accretion and increased protein synthesis

Hindlimb unloading results in muscle atrophy and a period of reloading has been shown to partially recover the lost muscle mass. Two of the mechanisms involved in this recovery of muscle mass are the activation of protein synthesis pathways and an increase in myonuclei number. The additional myonuclei are provided by satellite cells that are activated by the mechanical stress associated with the reloading of the muscles and eventually incorporated into the muscle fibers. Amino acid supplementation with exercise also can increase skeletal muscle mass through enhancement of protein synthesis and nucleotide supplements can promote cell cycle activity.

Source: Nutrition Research - October 22, 2016 Category: Nutrition Authors: Ryosuke Nakanishi, Yusuke Hirayama, Minoru Tanaka, Noriaki Maeshige, Hiroyo Kondo, Akihiko Ishihara, Roland R. Roy, Hidemi Fujino Tags: Original Research Source Type: research