Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

Conclusions: These results highlight NEDD8-pathway inhibition by pevonedistat as a potentially effective treatment for poorly differentiated, clinically aggressive CRC.

Source: JNCI - October 21, 2016 Category: Cancer & Oncology Authors: Picco, G., Petti, C., Sassi, F., Grillone, K., Migliardi, G., Rossi, T., Isella, C., Di Nicolantonio, F., Sarotto, I., Sapino, A., Bardelli, A., Trusolino, L., Bertotti, A., Medico, E. Tags: Article Source Type: research