Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats.

CONCLUSION: In this study, we demonstrate that SNL-induced CaV3.2 upregulation in the spinal cord and DRG was attenuated by intrathecal infusion of mibefradil or ethosuximide. No obvious neurotoxicity effects were observed in all the tested groups. Our data suggest that continuous intrathecal infusion of TCC blockers may be considered as a promising alternative for the treatment of nerve injury-induced pain.
PMID: 27765616 [PubMed - as supplied by publisher]

Source: Acta Anaesthesiologica Taiwanica - October 16, 2016 Category: Anesthesiology Authors: Shiue SJ, Wang CH, Wang TY, Chen YC, Cheng JK Tags: Acta Anaesthesiol Taiwan Source Type: research