Impact of Timing of Radiotherapy in Patients with Newly Diagnosed Glioblastoma

Glioblastoma (GBM) is an aggressive and rapidly progressive brain tumor. Several prior series have demonstrated a survival advantage associated with greater extent of surgical resection [1,2]. Due to the benefit of the reduction of tumor burden and the concern for rapid recurrence of these aggressive tumors, a bias amongst practitioners has existed for minimizing the time delay between surgery and the commencement of radiotherapy (RT). It has been assumed that starting RT prior to tumor repopulation may lead to an advantage for patients with greater extent of resection.

Source: Clinical Neurology and Neurosurgery - October 21, 2016 Category: Neurosurgery Authors: David M. Randolph, Emory R. McTyre, Anna K. Paulsson, Jordan A. Holmes, William H. Hinson, Glenn J. Lesser, Roy Strowd, Hui-Wen Lo, Adrian W. Laxton, Stephen B. Tatter, Waldemar Debinski, Michael D. Chan Source Type: research