Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis

Conclusions: USE1 proteins are frequently overexpressed in lung cancer, and missense mutations in USE1 prolong the half-life of the protein, promoting tumor formation. Our findings reveal novel roles for USE1 in lung cancer and the possible use of USE1 as a novel biomarker and therapeutic target for lung cancer treatment.

Source: JNCI - October 20, 2016 Category: Cancer & Oncology Authors: Kim, S.-J., Hyeong Lee, T., Hee Nam, S., Kim, J.-H., Oh, S., Sook Cho, Y., Sup Lee, M., Choi, S., Lee, P. C. W. Tags: Article Source Type: research