Renin Angiotensin Aldosterone System Inhibitors In Hypertension: Is There Evidence For Benefit Independent Of Blood Pressure Reduction?

Abstract.The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the pathogenesis of hypertension (HTN). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are first line anti-HTN drug classes that are potent, effective and largely safe. Direct renin inhibitors (DRIs) have shown similar blood pressure (BP) reduction but more side effects. The efficacy of ACEIs and ARBs (for cardiovascular, cerebrovascular and renal protection) has been promoted to extend beyond what could be explained by BP reduction alone.

Source: Progress in Cardiovascular Diseases - October 20, 2016 Category: Cardiology Authors: Chirag Bavishi, Sripal Bangalore, Franz H. Messerli Source Type: research