Development of lipopolysaccharide ‐mimicking peptides and their immunoprotectivity against Vibrio cholerae serogroup O1

In conclusion, these peptides are mimicking LPS and can potentially act as vaccine candidates against V. cholerae. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. Phage particles displaying 12 amino acid peptides were selected from phage library using camelid VHH against Vibrio cholerae LPS in a three rounds of panning. Because these peptides are mimicking, the antigenic epitopes of LPS, therefore, are used as vaccine candidate to immunized mice. These peptides induced the immune system against V. cholerae and inhibit its attachment and colonization.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fpsc.2930

Source: Journal of Peptide Science - September 30, 2016 Category: Biochemistry Authors: Fatemeh Mohammad Pour Ghazi, Seyed Latif Mousavi Gargari Tags: Research Article Source Type: research

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