High fat western diet induced obesity contributes to increased tumor growth in mouse models of human colon cancer

In this study, our objective was to establish mouse models to examine the effects of high fat western diet-induced obesity on the growth of human colon cancer tumor xenografts, and examine potential mechanisms driving obesity-linked human colon cancer tumor growth. We hypothesize that mice rendered insulin resistant due to consumption of a high fat western diet will show increased and accelerated tumor growth.

Source: Nutrition Research - October 19, 2016 Category: Nutrition Authors: Ann Marie O'Neill, Christine M. Burrington, Erin A. Gillaspie, Darin T. Lynch, Melissa J. Horsman, Michael W. Greene Tags: Original Research Source Type: research