Age-associated changes in human hematopoietic stem cells

Aging has a broad impact on the function of the human hematopoietic system. This review will focus primarily on the effect of aging on the human hematopoietic stem cell (HSC) population. With age, even though human HSCs increase in number, they have decreased self-renewal capacity and reconstitution potential upon transplantation. As a population, human HSCs become more myeloid-biased in their differentiation potential. This is likely due to the human HSC population becoming more clonal with age, selecting for myeloid-biased HSC clones.

Source: Seminars in Hematology - October 19, 2016 Category: Hematology Authors: Wendy W. Pang, Stanley L. Schrier, Irving L. Weissman Source Type: research