Atypical neuroleptic malignant syndrome with long ‐acting paliperidone

Neuroleptic malignant syndrome (NMS) is a rare but serious and potentially fatal adverse effect caused by dopamine receptor blockade associated with the use of antipsychotic agents. The incidence of NMS has been estimated to range from 0.01% to 2.4%, and the syndrome can occur in any age group, including the elderly. Classical features include mental status changes, muscular rigidity, hyperthermia, and symptoms suggestive of autonomic instability (e.g., presyncope, tachycardia, diaphoresis), with elevated creatine kinase and white blood cell count as common laboratory findings.

Source: The Brown University Psychopharmacology Update - October 19, 2016 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug ‐Drug Interactions Source Type: research