Attention deficit-hyperactivity disorder suffers from mitochondrial dysfunction

Conclusions Since cybrids are shown to replicate mitochondrial defects seen in post-mortem brains, these observed defects in ADHD cybrids strongly suggest mitochondrial pathology in this disorder. General significance Mitochondrial defects are detected in ADHD cybrids created from patients'platelets, implying bioenergetics crisis in the mitochondria could be a contributory factor for ADHD pathology and/or phenotypes.

Source: BBA Clinical - October 19, 2016 Category: Biochemistry Source Type: research