The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging

In the classical model of hematopoiesis, HSCs sit at the apex of a developmental hierarchy. HSCs are self-renewing and give rise to all mature myeloid and lymphoid cell lineages. Although they are multipotent and self-renewing, HSCs are relatively quiescent in order to maintain an indefinite pool of HSCs [1]. The pool of HSCs contains multipotent progenitors (MPP), short-term HSCs (ST-HSCs), and long-term HSCs (LT-HSCs). The balance of HSC self-renewal with multi-lineage differentiation is critical for hematopoietic tissue homeostasis [2].

Source: Seminars in Hematology - October 18, 2016 Category: Hematology Authors: Sarah E. Latchney, Laura M. Calvi Source Type: research