Concise Review: In Vitro Formation of Bone-Like Nodules Sheds Light on the Application of Stem Cells for Bone Regeneration

This article also highlights the limitations of current translational applications of stem cells and opportunities to use the bone-like nodule model for bone regenerative therapies.

Significance
Harnessing the differentiation of stem cells into bone-forming cells represents an intriguing avenue for the creation of functional skeletal tissues. Therefore, a profound understanding of bone development and morphogenesis sheds light on the regenerative application of stem cells in orthopedics and dentistry. In this concise review, studies deciphering the mechanisms that govern osteoblast commitment and differentiation are summarized. This article highlights the limitations of current translational applications of stem cells and the opportunities to use the bone-like nodule model for bone regenerative therapies.

Source: Stem Cells Translational Medicine - October 18, 2016 Category: Stem Cells Authors: Mechiche Alami, S., Gangloff, S. C., Laurent-Maquin, D., Wang, Y., Kerdjoudj, H. Tags: Concise Review, Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research