Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-{beta}1

This study makes a significant contribution to demonstrate that autophagy could improve the immunosuppression of CD4+ T cells by mesenchymal stem cells through transforming growth factor-β1. Therefore, regulation of autophagy in MSCs would provide a promising strategy to improve the therapeutic efficacy of these cells.

Source: Stem Cells Translational Medicine - October 18, 2016 Category: Stem Cells Authors: Gao, L., Cen, S., Wang, P., Xie, Z., Liu, Z., Deng, W., Su, H., Wu, X., Wang, S., Li, J., Ouyang, Y., Wu, Y., Shen, H. Tags: Mesenchymal Stem Cells, Cell-Based Drug Development, Screening, and Toxicology Source Type: research