SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a) [Original Articles]

Conclusions— Human SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp(a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a).

http://circgenetics.ahajournals.org/cgi/content/short/9/5/408?rss=1

Source: Circulation: Cardiovascular Genetics - October 17, 2016 Category: Cardiology Authors: Yang, X., Sethi, A., Yanek, L. R., Knapper, C., Nordestgaard, B. G., Tybjaerg-Hansen, A., Becker, D. M., Mathias, R. A., Remaley, A. T., Becker, L. C. Tags: Lipids and Cholesterol, Genetic, Association Studies, Functional Genomics Original Articles Source Type: research

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