Topoisomerases and the regulation of neural function

Nature Reviews Neuroscience 17, 673 (2016).
doi:10.1038/nrn.2016.101

Author: Peter J. McKinnon
Topoisomerases are unique enzymes that regulate torsional stress in DNA to enable essential genome functions, including DNA replication and transcription. Although all cells in an organism require topoisomerases to maintain normal function, the nervous system in particular shows a vital need for these enzymes. Indeed,

Source: Nature Reviews Neuroscience - September 14, 2016 Category: Neuroscience Authors: Peter J. McKinnon Tags: Progress Source Type: research