A high-fat diet differentially regulates glutathione phenotypes in the obesity-prone mouse strains DBA/2J, C57BL/6J, and AKR/J

The ubiquitous tripeptide glutathione (GSH) is a critical component of the endogenous antioxidant defense system. Tissue GSH concentrations and redox status (GSH/GSSG) are genetically controlled, but it is unclear whether interactions between genetic background and diet affect GSH homeostasis. The current study tested the hypothesis that a high-fat diet regulates GSH homeostasis in a manner dependent on genetic background. At four months of age, female mice representing three obesity-prone inbred strains ― C57BL/6J (B6), DBA/2J (D2), and AKR/J (AKR) ― were randomly assigned to consume a control (10% energy from fat) or high-fat (62% energy from fat) diet for ten weeks (n=5/diet/strain).

Source: Nutrition Research - October 16, 2016 Category: Nutrition Authors: Katie M. Norris, Whitney Okie, Woo Kyun Kim, Roshan Adhikari, Sarah Yoo, Stephanie King, Robert Pazdro Tags: Original Research Source Type: research