Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study

We examined associations with objectively classified (a) cognitive status at baseline (not impaired congnitive (NIC) controls vs MCI) and (b) stability or transition of cognitive status across a 4-year interval (stable NIC–NIC vs chronic MCI–MCI or transitional NIC–MCI).

Results:
Using logistic regression, indicators of vascular health, both independently and interactively with APOE 4, were associated with risk of MCI at baseline and/or associated with MCI conversion or MCI stability over the retest interval.

Discussion:
Several vascular health markers of aging predict MCI risk. Interactively, APOE 4 may intensify the vascular health risk for MCI.

Source: Journals of Gerontology: Series B Psychological Sciences and Social Sciences - October 16, 2016 Category: Geriatrics Authors: DeCarlo, C. A., MacDonald, S. W. S., Vergote, D., Jhamandas, J., Westaway, D., Dixon, R. A. Tags: Original Research Report Source Type: research