Management of postoperative pain after Lumbar surgery —pregabalin for one day and 14 days—a randomized, triple-blinded, placebo-controlled study

Low back pain (LBP) is considered as vast economic burden for health care systems. The estimated incidence for the general population is about 60 –80% [1,2]. Despite the progress in understanding acute pain physiology during recent decades, eighty percent of patients still suffer from post-operative discomfort [3]. The pain depends on how many Vertebrae has been operated and the invasiveness of our approach [4]. Unsuccessful control of this pain can cause muscle wasting, depression, sensitization of the nervous system, depression, hyper reactivity of autonomic system and stiffening of the joints [5,6].

Source: Clinical Neurology and Neurosurgery - October 15, 2016 Category: Neurosurgery Authors: Mohammad Zarei, Arvin Najafi, Pejman Mansouri, Sadaf Sadeghi-Yazdankhah, Houshang Saberi, Mehran Moradi, Mahmoud Farzan Source Type: research