Phenylpropanoids from Cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in CHO cells stably expressing amyloid precursor protein

Beta-amyloid (A β) is a substance of Alzheimer's disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD. The methanol extract of cinnamon bark efficiently reduced Aβ40 production in CHO cells - stably expressing APP (APP-CHO), as determined by ELISA.
Source: Nutrition Research - Category: Nutrition Authors: Tags: Original Research Source Type: research