Genetic divergence in the engram for chronic alcohol exposure

Genetic factors that influence the transition from initial drinking to dependence remain enigmatic. Recent studies have leveraged chronic intermittent ethanol (CIE) paradigms to measure changes in brain gene expression in a single strain at 0, 8, 72  h, and even 7 days following CIE. We extend these findings using LCM RNA-seq to profile expression in 11 brain regions in two inbred strains—C57BL/6J (B6) and DBA/2J (D2)—72 h following multiple cycles of ethanol self-administration and CIE. Linear models identified differential expression ba sed on treatment, region, strain, or interactions with treatment.

Source: Alcohol - October 14, 2016 Category: Addiction Authors: Megan K. Mulligan, Khyobeni Mozhui, Ashutosh K. Pandey, Maren L. Smith, Suzhen Gong, Jesse Ingels, Michael F. Miles, Marcelo F. Lopez, Lu Lu, Robert W. Williams Source Type: research