Effect of gamma-carboxylase inhibition on serum osteocalcin may be partially protective against developing diabetic cardiomyopathy in type 2 diabetic rats

Conclusion:
Undercarboxylated osteocalcin was suggested to have protective effects against diabetic cardiomyopathy, possibly through direct action on upregulated G protein–coupled receptor family C group 6 member A and indirectly via adiponectin. These effects may be mediated through antagonizing oxidative stress and apoptosis.

Source: Diabetes and Vascular Disease Research - October 14, 2016 Category: Endocrinology Authors: Gamal, S. M., Sadek, N. B., Rashed, L. A., Shawky, H. M., Gamal El-Din, M. M. Tags: Original Articles Source Type: research