New Role of Hispidulin in Lipid Metabolism: PPAR α Activator

In this study, the regulating role of hispidulin on the mRNA expression level of enzymes involved in lipid metabolism was examinedin vitro andin vivo. Moreover, thein vivo lipid-modulating effect of hispidulin was compared with that of fenofibrate, a classical PPAR α agonist. Our results in present study demonstrated that hispidulin can directly bind to and activate PPARα as an agonist and thus modulate the downstream lipid-metabolizing genes. Moreover, hispidulin could attenuate dyslipidemia in high fat diet induced dyslipidemia rat model. Although further studies are needed, this study provided evidence for the potential use of hispidulin in dyslipidemia management.

Source: Lipids - October 14, 2016 Category: Lipidology Source Type: research