Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection

Conclusions. A role for MMP/TIMP balance in dolichoectasia appears more prominent in HIV-negative individuals, while apoptosis, mediated by caspase 3, is the most important determinant of media thinning in HIV-infected individuals. Furthermore, apoptosis and media thickness appear to mediate the effects of MMP in the HIV-infected population.

Source: The Journal of Infectious Diseases - October 12, 2016 Category: Infectious Diseases Authors: Gutierrez, J., Menshawy, K., Goldman, J., Dwork, A. J., Elkind, M. S. V., Marshall, R. S., Morgello, S. Tags: HIV/AIDS Source Type: research