Linezolid for Infants and Toddlers With Disseminated Tuberculosis: First Steps

Conclusions. We identified the linezolid AUC0–24/MIC target for optimal efficacy against pediatric intracellular tuberculosis, and an AUC0–24 threshold associated with mitochondrial inhibition. These constitute a therapeutic window to be targeted for optimal linezolid doses in children with tuberculosis.

Source: Clinical Infectious Diseases - October 13, 2016 Category: Infectious Diseases Authors: Deshpande, D., Srivastava, S., Pasipanodya, J. G., Bush, S. J., Nuermberger, E., Swaminathan, S., Gumbo, T. Tags: A DEVELOPMENT PARADIGM FOR NOVEL COMBINATION REGIMENS FOR MULTIDRUG-RESISTANT AND DRUG-SUSCEPTIBLE TUBERCULOSIS IN CHILDREN: FLAME FOR WORK AND PLAY Source Type: research