Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children With Tuberculosis: Bread Crumb Trails in Random Forests

Conclusions. We have identified new antibiotic target concentrations, which are potential biomarkers associated with treatment failure and death in children with tuberculosis.

Source: Clinical Infectious Diseases - October 13, 2016 Category: Infectious Diseases Authors: Swaminathan, S., Pasipanodya, J. G., Ramachandran, G., Hemanth Kumar, A. K., Srivastava, S., Deshpande, D., Nuermberger, E., Gumbo, T. Tags: A DEVELOPMENT PARADIGM FOR NOVEL COMBINATION REGIMENS FOR MULTIDRUG-RESISTANT AND DRUG-SUSCEPTIBLE TUBERCULOSIS IN CHILDREN: FLAME FOR WORK AND PLAY Source Type: research