Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination

This study was designed to investigate the heterologous effects of MV and DTP in 302 Gambian infants. The results support a sex-differential immunosuppressive effect of DTP on innate proinflammatory responses and T-cell immunity. Males but not females receiving MV had enhanced proinflammatory innate responses. The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for the effects on innate immunity. When both vaccines were administered together, purified protein derivative responses were enhanced in females but downregulated in males. Collectively, these data indicate immunological effects that could account for heterologous effects of MV and DTP, to take forward into prospective trials.

Source: Clinical Infectious Diseases - October 13, 2016 Category: Infectious Diseases Authors: Noho-Konteh, F., Adetifa, J. U., Cox, M., Hossin, S., Reynolds, J., Le, M. T., Sanyang, L. C., Drammeh, A., Plebanski, M., Forster, T., Dickinson, P., Ghazal, P., Whittle, H., Rowland-Jones, S. L., Sutherland, J. S., Flanagan, K. L. Tags: VACCINES Source Type: research