NF- κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms

The NF- κB pathway, a critical regulator of apoptosis, plays a key role in many normal cellular functions. Genetic alterations and other mechanisms leading to constitutive activation of the NF-κB pathway contribute to cancer development, progression and therapy resistance by activation of downstream anti- apoptotic pathways, unfavorable microenvironment interactions, and gene dysregulation. Not surprisingly, given its importance to normal and cancer cell function, the NF-κB pathway has emerged as a target for therapy.

Source: Blood Reviews - October 12, 2016 Category: Hematology Authors: Li Yu, Ling Li, L. Jeffrey Medeiros, Ken H. Young Tags: Review Source Type: research