Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response

We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0  g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5–19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60 mm Hg) using dual chamber arteriograph. The uterine artery di ameter stabilized at 20 mm Hg, showed passive distension at 40 mm Hg, and redeveloped tone at 60 mm Hg.

Source: Alcohol - October 12, 2016 Category: Addiction Authors: Vishal D. Naik, Emilie R. Lunde-Young, Katie L. Davis-Anderson, Marcus Orzabal, Ivan Ivanov, Jayanth Ramadoss Source Type: research